DeRozan top-scored for the Bulls with 28 points, while Coby White added 24 and Nikola Vucevic made his fourth straight double-double in a video game in which the lead altered hands 12 times.
Triumph extended the Eastern Conference leaders winning go to 6 games.
The Pacers, who had 6 gamers missing through Covid-19 procedures, have now lost 3 in a row.
LeBron James scored 43 points and included 14 rebounds the day after his 37th birthday to lead the Los Angeles Lakers to a 139-106 demolition of the Portland Trail Blazers.
James reached double figures in points with less than six minutes played, and taped a double-double inside the very first half.
Team-mate Russell Westbrook posted a triple-double – 15 points, 13 rebounds and 12 assists – while Ben McLemore led the Trail Blazers with 28 points off the bench.
The Boston Celtics beat the Phoenix Suns 123-108, while Trae Young made 35 points and 11 assists as the Atlanta Hawks overcame a 16-point deficit to beat the Cleveland Cavaliers 121-118.
Six Miami Heat players reached double figures as they held back the Houston Rockets 120-110 for a 5th successive win, and the Memphis Grizzlies made it four in a row with a 118-105 success over the San Antonio Spurs.
Donovan Mitchell returned from a two-game absence through injury to score a season-high 39 points as the Utah Jazz beat the Minnesota Timberwolves 120-108.
The Dallas Mavericks beat the Sacramento Kings 112-96, the Toronto Raptors conquered the LA Clippers 116-108 and the Oklahoma City Thunder beat the New York Knicks 95-80.
DeMar DeRozan makes the winning three-pointer for the Chicago BullsDeMar DeRozan scored a buzzer-beating three-pointer to give the Chicago Bulls a 108-106 win at the Indiana Pacers.